Giovanni Luca Gravina Selected Research

ozarelix

9/2010

Ozarelix, a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors.

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Giovanni Luca Gravina Research Topics

Disease

59	Neoplasms (Cancer) 01/2022 - 07/2004
51	Prostatic Neoplasms (Prostate Cancer) 12/2019 - 03/2003
19	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 06/2014
14	Neoplasm Metastasis (Metastasis) 02/2022 - 05/2004
8	Carcinoma (Carcinomatosis) 12/2014 - 09/2002
7	Glioma (Gliomas) 01/2022 - 12/2014
6	Rhabdomyosarcoma 10/2021 - 01/2011
4	Pain (Aches) 02/2022 - 01/2015
4	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 08/2016 - 04/2004
3	Embryonal Rhabdomyosarcoma 10/2017 - 01/2011
2	Breast Neoplasms (Breast Cancer) 12/2020 - 05/2014
2	Brain Neoplasms (Brain Tumor) 01/2020 - 05/2018
2	Osteolysis 12/2019 - 09/2015
2	Necrosis 05/2017 - 03/2008
2	Carcinogenesis 02/2017 - 01/2014
2	Inflammation (Inflammations) 01/2017 - 05/2014
1	Infertility (Sterility) 03/2021
1	Endometrial Neoplasms (Endometrial Cancer) 04/2020

Drug/Important Bio-Agent (IBA)

13	AndrogensIBA 09/2016 - 03/2003
10	bicalutamide (Casodex)FDA LinkGeneric 12/2011 - 09/2002
9	Biological ProductsIBA 12/2019 - 05/2005
9	Hormones (Hormone)IBA 12/2017 - 06/2009
9	ErbB Receptors (EGF Receptor)IBA 10/2011 - 03/2003
8	Pharmaceutical PreparationsIBA 01/2022 - 08/2008
7	Androgen Receptors (Androgen Receptor)IBA 12/2017 - 07/2004
7	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 01/2011
6	Docetaxel (Taxotere)FDA Link 12/2019 - 06/2009
6	Tyrosine Kinase InhibitorsIBA 10/2009 - 03/2003
5	Phosphotransferases (Kinase)IBA 01/2020 - 07/2004
5	Cyclin D1IBA 12/2017 - 06/2009
5	Gefitinib (Iressa)FDA Link 11/2007 - 03/2003
4	Histone Deacetylase InhibitorsIBA 10/2021 - 03/2012
4	Temozolomide (Temodar)FDA LinkGeneric 01/2020 - 01/2017
4	EphrinsIBA 01/2020 - 10/2017
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 09/2018 - 01/2011
4	Azacitidine (5 Azacytidine)FDA Link 07/2016 - 05/2008
4	selinexorIBA 01/2016 - 10/2014
4	Epidermal Growth Factor (EGF)IBA 11/2006 - 05/2004
3	thiamine triphosphorate (TTP)IBA 01/2020 - 06/2014
3	Mechanistic Target of Rapamycin Complex 2IBA 10/2019 - 08/2011
3	Mechanistic Target of Rapamycin Complex 1IBA 10/2019 - 08/2011
3	Proteins (Proteins, Gene)FDA Link 10/2019 - 05/2008
3	belinostatIBA 10/2019 - 03/2012
3	U 0126 (UO 126)IBA 09/2018 - 01/2011
3	SurvivinIBA 01/2016 - 06/2014
3	Androgen Antagonists (Antiandrogens)IBA 10/2009 - 09/2002
2	PBI-05204IBA 01/2022 - 01/2020
2	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2020 - 04/2019
2	CytokinesIBA 08/2020 - 03/2008
2	pyrimidineIBA 05/2020 - 01/2016
2	trans-sodium crocetinate (crocetin)IBA 01/2020 - 01/2014
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2020 - 01/2014
2	Erythropoietin FDA Link 01/2020 - 10/2017
2	EphA1 Receptor (Eph Receptor)IBA 01/2020 - 05/2018
2	taxaneIBA 12/2019 - 05/2014
2	Collagen Type I (Type I Collagen)IBA 12/2019 - 09/2015
2	Therapeutic UsesIBA 10/2019 - 12/2015
2	AntioxidantsIBA 04/2019 - 02/2008
2	givinostatIBA 01/2019 - 01/2019
2	givinostat hydrochlorideIBA 01/2019 - 01/2019
2	Histone Deacetylases (Histone Deacetylase)IBA 01/2019 - 01/2017
2	EnzymesIBA 02/2017 - 09/2009
2	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 02/2017 - 09/2009
2	Nerve Growth Factor (NGF)IBA 07/2016 - 01/2007
2	Exportin 1 ProteinIBA 12/2015 - 12/2014
2	KPT-251IBA 12/2015 - 10/2014
2	Analgesics (Analgesic Drugs)IBA 01/2015 - 07/2005
2	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 06/2014 - 01/2011
2	palomid 529IBA 06/2014 - 08/2011
2	crocinIBA 01/2014 - 01/2013
2	MethyltransferasesIBA 03/2013 - 12/2011
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 10/2011 - 10/2009
2	Cisplatin (Platino)FDA LinkGeneric 08/2011 - 06/2009
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 11/2009 - 08/2007
2	TensinsIBA 11/2009 - 08/2007
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2008 - 03/2008
2	Finasteride (Propecia)FDA LinkGeneric 07/2008 - 04/2005
2	lestaurtinibIBA 09/2007 - 01/2007
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 04/2005 - 05/2004
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2022
1	Cell-Penetrating PeptidesIBA 01/2022
1	Peptides (Polypeptides)IBA 01/2022
1	Cardiac GlycosidesIBA 01/2022
1	oleandrinIBA 01/2022
1	sulforaphaneIBA 10/2021
1	entinostat (MS 275)IBA 10/2021
1	Cyclin AIBA 01/2021
1	romidepsin (FK228)FDA Link 01/2021
1	Carisoprodol (Soma)FDA LinkGeneric 05/2020

Therapy/Procedure

29	Radiotherapy 01/2022 - 01/2010
23	Therapeutics 10/2021 - 07/2004
9	Drug Therapy (Chemotherapy) 02/2020 - 09/2013
7	Castration 12/2019 - 10/2009
3	Cryosurgery 02/2022 - 01/2015
2	Aftercare (After-Treatment) 01/2017 - 01/2015
2	Radiofrequency Ablation 08/2016 - 03/2016
2	Prostatectomy (Retropubic Prostatectomy) 09/2007 - 09/2007
1	Ablation Techniques 02/2022
1	Vertebroplasty 05/2020
1	Brachytherapy 04/2020